Melvin’s recent JBC paper was the subject of this recent interview in ASBMB Today. Melvin showed that an evolutionarily conserved phosphorylation site in caspases uses a common allosteric network to decrease the activity of caspase-3. A mutation in mammalian caspase-3 introduces a kill-switch into the enzyme so that it is turned off when the site is phosphorylated.
Melvin’s paper was published recently in the Journal of Biological Chemistry.
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